BCH210H1 Lecture Notes - Lecture 29: Pyruvate Dehydrogenase, Citric Acid Cycle, Pyruvic Acid
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BCH210H1 Full Course Notes
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Case study: soon-yi part iii mitochondrial bioenergetics: the kreb"s cycle: an overview, the pyruvate dehydrogenase complex, steps in the krebs cycle. Soon-yi: part 3: flying over the sand: mitochondrial bioenergetics. Soon-yi picks up the pace as she runs into the rising sun. She is hitting a speed of 200 m/min and has covered 500m of her 10km run this morning. While glycolysis supported her initial muscle atp needs, she relies now on the more efficient. Her muscles receive a steady supply of oxygen from blood. Soon-yi"s mitochondria, rapidly take up pyruvate from aerobic glycolysis. Pyruvate coming from glycolysis, now entered by transporter into mitochondria into matrix. Pyruvate is converted to acetyl coa via the pyruvate dehydrogenase (pdh) complex: use nad and coenzyme a to make acetyl coa, make acetyl coa and release co2. The complex has 3 enzymes and 5 coenzymes: thiamine, fad, nad+ and coenzyme a, coenzyme a has a very reactive sh group that forms acyl thioesters.
