BCH210H1 Lecture Notes - Lecture 5: Pancreatic Ribonuclease, Beta Sheet, Endoplasmic Reticulum

• School: UTSG
• Department: Biochemical Engineering and Applied Chemistry
• Course: BCH210H1
• Professor: Reinhart Reithmeier

Document Summary

There are some proteins that literally walk on these tracks" (the fibers), all the while carrying things like lipid vesicles on their backs! Actin is very small (~400 amino acids) and dynamic (exist in both monomeric form and filamented form) 8 connected helix segments form heme pocket to bind fe- heme: helices fold via beta turns; several turns contain pro residues xi. Strongly hydrophobic core (contains v, l, i, m, f: ex. Note that this is the folded active state of the protein; if you unfolded it, you"d lose protein activity. Made up of helices, sheets, and turns/loops: mechanism of ribonuclease: His-12 grabs a proton by nucleophilic attack, leaving a "ve charge on the o atom of the ribose sugar. The 2 electrons on the o are now going to attack the p of phosphate group, which pushes the electrons in the order shown by the arrows.