BCH210H1 Lecture Notes - Lecture 36: Ketone Bodies, Atp Synthase, Glycolysis

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Stavroula Andreopoulos

Document Summary

Do(cid:374)"t (cid:374)eed to k(cid:374)o(cid:449) the stru(cid:272)tures of the (cid:373)ole(cid:272)ules, (cid:449)e (cid:374)eed to k(cid:374)o(cid:449) (cid:449)hat the (cid:373)ole(cid:272)ule has, if it has a phosphate etc. If (cid:449)e do(cid:374)"t ha(cid:448)e o(cid:454)(cid:455)ge(cid:374), these path(cid:449)a(cid:455)s (cid:271)a(cid:272)k up a(cid:374)d (cid:272)a(cid:374)t pro(cid:272)eed. Alcohol dehydeogenase is in the liver and it breaks down ethanol. Pyrophosphate or ppi can be hydrolyzed to form 2pi which generates more energy to drive this reaction forward. The problem with the amp is that we need a 2nd atp to make adp so that atp synthase can reform atp. When breaking down ethanol, we produce lots of nadh and protons. We are making lots of acetyl coa that could be used in tca, but it could be regulated in some cases. For acetate metabolism, we would need 2 atps. Because she has(cid:374)"t eate(cid:374), glu(cid:272)ago(cid:374) is a(cid:272)ti(cid:448)e. so(cid:373)e al(cid:272)ohols ha(cid:448)e sugars (cid:449)hi(cid:272)h is glu(cid:272)ose (cid:449)hi(cid:272)h promotes insulin release which inhibits glucagon. Gng is an inactive pathway because insuli signaling is occurring.