BCH210H1 Lecture Notes - Lecture 10: Blood Sugar, Prnp, Bovine Spongiform Encephalopathy

• School: UTSG
• Department: Biochemistry
• Course: BCH210H1
• Professor: Reinhart Reithmeier

Document Summary

4 subunits: 2 subunits, 2 subunits. The average p of the chain favours neither or configurations. Substitution of glutamate valine: pushes the tendency toward -sheet configuration. Glioblastoma: erbb2 erbb2: growth factor that facilitates division & growth. Mutation receptor turns on" without ligand uncontrolled tyrosine kinase activity uncontrollable cell growth. Val664glu mutation: valine in position 664 mutated into glutamate. Secreted when blood sugar is low tells body to break down stored glycogen: secreted by pancreas, binds to liver cell receptor. Probably of and regions very similar. Therefore: equal propensity to adopt either form (can be either, depending on concentration) Val5leu mutation: leucine similar properties as valine (charged & polar, better -former. Caused by prion protein misfoliding (prnp- prion protein) Normal protein found on membrane of all cells. Prion: -helices -helices, different from -helices or -sheets, not as tightly coiled & triangular-ish versions of -helices. Leads to large amounts of aggregation in brain tissue.