PSYC62H3 Lecture Notes - Lecture 1: Agonism, Ligand-Gated Ion Channel, Agonist
29 Jan 2018
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Document Summary
How a drug is administered and absorbed into the bloodstream. How it permeates different body parts, and is eliminated from the body. Absorption - the passage of a drug from the site of administration to the bloodstream. Absorption relies on a drug"s ability to passively diffuse through membranes. Most drug absorption occurs in the small intestine (orally) Liberation - the process of drug molecules separating from the pill or solution it was delivered in. Distribution - a drug must pass through a membrane and this depends on the drug"s. Diffusion works best for nonionized drug molecules which have a neutral route of administration ph. Passage of drug from bloodstream into organs. Distribution phase affects a drug"s bioavailability, which is the ability of a drug to reach a site of action. Bioavailability of psychoactive drugs depends on the drug reaching the central nervous system.
