BIOB34H3 Lecture Notes - Lecture 24: Lipid Bilayer, Goldman Equation, Resting Potential
Document Summary
Lecture 24: sodium gradient push sodium out of cell and favours it in the ecm, sodium diffuses into the cell until +72 mv. Inside of cell is 72 mv more positive than the outside: chloride is favoured outside of the cell, moves into the cell until the cell is -84mv. Inside of the cell is 84mv more negative than the outside of the cell: no net movement of chloride ions at this point. If we change concentration of ions, it changes the equilibrium potential of that ion. If concentrations were equal, we would not have any ion movement across membrane no gradient, no movement: can get values that are significantly far from zero. Ions can leak across the phospholipid membranes: sodium and potassium leak channels in the phospholipid bilayer, these channels are always open ions can enter as they please. At rest, neither na nor cl nor k at equilibrium: is resting membrane potential is a steady state.
