BIOB11H3 Lecture Notes - Lecture 9: Dna Polymerase I, Dna Supercoil, Cytosol
Document Summary
Interactions of specific mrnas with various proteins and micrornas determine translational control: three main types of translational control, 1. mrna localization where in the cell, 2. mrna translation yes/no, when, how often and rate, 3. mrna stability half life of mrna , how long is the message usable in translation. Translational control mrna translation in addition to localization, mrna translation is also regulated regulation determined by binding of specific proteins that are sensitive to needs of the cell at specific time and condition ex. translation of ferritin mrna, binds free iron in cytoplasm prevent toxicity: mrna translation regulated by iron regulatory protein(irp)repressor, low [iron] = irp binding to specific sequence in 5" utr, iron response element (ire) (cid:224) no translation of ferritin mrna, high [iron] = iron binds irp can"t bind to ire (loss of affinity), ferritin mrna translated making ferritin protein.
