BIOB11H3 Lecture 18: Bio B11 Lec 18 C 14.docx
Document Summary
Cell cycle iii: biochemical regulation of mitosis and mechanisms of cytokinesis. Dyneins drive towards the minus (-) end of the track. Kinesins drive towards the plus (+) end of the track. See previous lecture notes for explanation of slide! Fig 14-24: the mitotic spindle of an animal cell: the mitotic spindle of an animal cell. Each spindle pole contains a pair of centrioles surrounded by amorphous pericentriolar material at which the microtubules are nucleated. three types of spindle microtubules: astral, chromosomal, and polar spindle microtubules, are evident. All of the spindle mt"s which can number in the thousands have their minus ends pointed toward the centrosome. (from previous lecture notes) Meanwhile the chromosomes have become attached to the chromosomal mt"s. Ultimately the chrom"s are moved to the center of the spindle, midway between the poles. Poleward chromosome movements are mediated by minus-end-directed motors (cytoplasmic dynein!) residing @ the kinetochore (2).
