BIOB11H3 Lecture Notes - Lecture 8: Chromatin Immunoprecipitation, Acetyl Group, Fibroblast
Document Summary
Genome is usually circular dsdna w/ little spacing between the transcription units. Genes are often grouped together based on function similarity allows for coordinated regulation of the entire group. Changes in gene expression occurs rapidly for the response to changes in nutritional and physical env. Presence of lactose as the energy source turns on the production of (cid:2185)(cid:2202)(cid:2201)(cid:2186)(cid:2201)(cid:2187) (the enzyme that breaks down lactose) Bacterial genes encoding proteins/enzymes involved in the same metabolic pathway are grouped in a functional cluster known as an operon. Has: coordinated control, transcribed as one long mrna (polycistronic), mrna gets translated into indiv. About half of the genes in e. coli are clustered in operons. Transcription of operons as well as of isolated genes is controlled by an interplay between rnap and specific repressor and activator proteins. Composition of operons: promoter region: site where rnap binds to. In the absence of lactose, very few copies of enzyme are produced.
