BIOB10H3 Lecture 9: lec09 - ppt notes - alenxu

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12 Sep 2016
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Proteins that make up the cytoskeleton reside in the cytosol. The cytoskeletal elements are formed by polymers of proteins: formed by joining several protein subunits together. Rapid assembly and disassembly of these polymers is a key characteristic required for their function. Allows the movement of materials and organelles within cells. Required for cell motility and cell functions: e. g. phagocytosis. Four key functions: structure and support, intracellular transport, contractility and motility, spatial organization. Made up of three components: microtubules. Building blocks are made up of the protein tubulin. Tubulin subunits come in two forms: alpha helix, beta pleated, alpha and beta tubulin are very similar in their structure and fit together very well. The alpha-beta tubulin dimers are the building blocks of a long polymer: known as a protofilament. The protofilament is asymmetric: alpha tubulin on one end, beta tubulin on another end, gives protofilament property of polarity.

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