BIOB10H3 Lecture Notes - Lecture 11: Keratin, Paracellular Transport, Helicobacter Pylori
23 Sep 2016
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An organized network of extracellular materials present beyond the pm. Can regulate cell function: maintain cells in differentiated and functional state, e. g. mammary gland epithelial cells. Composed of a mesh of extended fibrous proteins that are secreted by the cell: collagens, proteoglycans, fibronectin, laminins. Different ecms contain differeing amount of proteins, depending upon function. Amount of water varies widely: bone vs blood. Amount of mineral present may vary: e. g. high calcium phosphate in bone. Gives bone its strength i. e. supporting role in skeleton. Family of secreted fibrous glycoproteins: secreted by. Collagen is the most abundant protein in the animal kingdom: most common ecm protein: Collagen is synthesized in the rer as pro-collagen": pro-collagen. Can form homotrimers or heterotrimers that wind around each other in a triple helix. Post translational processing: mature collagen then assembled into collagen fibrils, which in turn make up collagen fibres. Mutations in genes encoding some collagens can lead to severe diseases: mutations in type i collagen:
