PHS 4300 Lecture Notes - Lecture 6: Uremia, Rapidly Progressive Glomerulonephritis, Renal Colic

• School: University of Ottawa
• Department: Physiology
• Course: PHS 4300
• Professor: Frank Feiner

Document Summary

25% cardiac output: 1-2% medulla, 90% cortex. 99% (180l filtered/24 hrs. ) absorbed: 1% (1-1. 8l of urine) excreted a l l u d e. Glomerular filtration rate (gfr) rate at which plasma moves through glomerular capillaries. Units ml/min females 85-125ml/min, males 97-140ml/min for two kidneys children reach adult proportions by 2 years of age. Driving force for gfr - glomerular capillary hydrostatic pressure. Gfr = kf (pgc (pt + copgc)) Kf = ultrafiltration coefficient includes capillary surface area and fluid permeability. Gfr = kf x (pgc pbc) ( gc - bc) su(cid:396)fa(cid:272)e a(cid:396)ea hyd(cid:396)auli(cid:272) pe(cid:396)(cid:373)ea(cid:271)ility. Glomerular filtration rate (gfr) is the volume of fluid filtered from the glomerular capillaries i(cid:374)to bo(cid:449)(cid:373)a(cid:374)(cid:859)s (cid:272)apsule pe(cid:396) u(cid:374)it ti(cid:373)e. Clinically, gfr is measured to determine renal function. The amount of inulin filtered equals the glomerular filtration rate multiplied by the concentration of insulin in the plasma.