PHA 4107 Lecture Notes - Lecture 19: Monoamine Oxidase, Tricyclic Antidepressant, Tranylcypromine
12 Jul 2018
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Monoamine hypothesis: antidepressants increase the levels of one or. If there are a lot of autoreceptors, strong degrease in sero release= lower electrical transmission=reason for depression: fluoxetine, paroxetine, sertraline. Blocking (cid:884) adrenergic presynaptic receptor autoreceptor thereby increasing norepinephrine neurotransmission on serotonin neurons (heteroreceptors) thereby increasing serotonin neurotransmission. Inhibitors: also blocks 5ht receptors, trazodone, highly sedating. Increase 5ht levels and also block 5ht-2a and. Tetracycline: good for anxiety, cause antidepressant actions by stimulating. 5ht1a receptors but can cause se by stimulating. 5ht2a and 5ht2c receptors: enters via na+ channels. Isolated in 1943 synthesis: resistance less than to either drug alone, used for: utis, pcp (penumocytstis pneumonia) in. Inhibits synthesis of ergosterol and distrupt the fungal cell membrane: oral antifungal drug or topical ciclopirox, class member of echinocandins. Inhibit synthesis of -1-3-d-glucan and disrupt the fungal cell wall: class member of pyrimidine analogs, disrupt synthesis of rna and dna, route- topical/oral, used for ringworm, candida-skin, mouth and vulvovaginal and onychomycosis (nail infection)
