PHA 3112 Lecture Notes - Lecture 3: Coronary Artery Disease, Atheroma, Coronary Circulation
12 Mar 2018
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Document Summary
Two terms are interchangeable because: chd is characterized by insufficient delivery of oxygenated blood to the myocardium (ischemia) because of atherosclerotic coronary arteries. Common cause of chd: atherosclerosis of coronary arteries (causes progressive narrowing of the arterial lumen) Incidence increased in 20th century, then decreased due to better treatment. It is still the leading cause of death globally (17. 5m people) Risk factors: advancing age, african-american race, hypertension, diabetes, cigaretty smoking, low hdl cholesterol. Males at higher risk for development of hd (~10yrs earlier than women) Probable cause of chd: abnormal lipid metabolism: lipids are transported blood stream within lipoprotein spheres; on the surface of the spheres: apoproteins (mediate the binding of lipoprotein cell receptors. Atherosclerotic lesions: increase in size over time occludes the lumen of vessels. Clinically significant atherosclerotic plaque: within any of the 3 major coronary arteries: all 3 are normally simultaneously affected (some only have 1 or 2)
