PHA 3112 Lecture Notes - Lecture 10: Maraviroc, Palivizumab, Raltegravir

• School: University of Ottawa
• Department: Pharmacology
• Course: PHA 3112
• Professor: frankfeiner

Document Summary

**you will not be asked about what diseases the antibiotics are used to treat nor the symptoms of these diseases, unless these are stressed in lecture* 84-drugs that weaken the bacterial cell wall 1. 85-drugs that weaken the bacterial cell wall 2. Infectious disease drugs ?? used: 30% all hospitalized pts. Spme organisms impervious (respond poorly to current drugs) Drug toxicity (effective drugs limited by toxicity) Aerobic/anaerobic: requires/doesn"t require o2 to survive and grow. Gram stain (gram positive-> purple // gram negative-->pink) Narrow spectrum drugs (grm-positive cocci and gram positive bacilli) Active against only a few species of microorganisms. Broad spectrum (gram positive cocci and gram negative baccili) Selective toxicity (drug injures target organism, not host: drugs inhibit bacterial wall synthesis/activate enzmes that disrupt cell wall (penicillins,ephalosporins) 2: lethal inhibition of bacterial protein synthesis (gentamicin, non lethal inhibition of protein synthesis (tetracyclines)