PHA 3112 Lecture Notes - Lecture 6: Partial Thromboplastin Time, Coronary Vasospasm, Coronary Artery Disease
22 Mar 2017
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Error: page numbers corresponding to notes are wrong. Angina heart not getting enough blood shoulder/arm/jaw. O2 supply to heart < o2 demand. Sudden substernal (under breast bone) pain/pressure radiates to l (cid:494)referred pain(cid:495: chronic stable/exertional, variant /prinzmetal, unstable. Happens when coronary arteries are their normal size. Hard to distinguish: treat both the same way. /angiotensin receptor blocker + o2 + iv morphine. Drug interactions: safety alert: drugs for erectile dysfunction. Graft: between aorta-diseased coronary artery beyond plaque (shunt) Heart stopped (cardioplegia): heart-lung bypass machine needed (midcab) performed on beating heart don(cid:495)t have to stop the heart! artery right up to the point of blockage. Xray guided catheter inserted into femoral artery -> occluded coronary. Stenting: stainless steel mesh tube implanted to prevent re-stenosis. High cholesterol: all pts should receive cholesterol-lowering therapy. Platelet plug: platelet contact collagen on surface of damaged vessel, adhere to site of injury, activated -> massive platelet aggregation.
