MED 1201 Lecture Notes - Hematopoietic Stem Cell Transplantation, Tyrosine-Kinase Inhibitor, Flow Cytometry
20 Nov 2012
School
Department
Course
Professor
Document Summary
Most common leukemia in children (4 7 years) Lymphocyte problem (either b or t cell)! Night sweats, fever, weight loss (b symptoms) Blasts: no cytoplasm, big mauve nucleus, prominent nucleoli. Same as all (but differential shows increased myeloid lineage cells) Blasts: large mauve nucleus with cytoplasm + auer rods, cytoplasmic granules. Induction therapy (+cns prophylaxis), consolidation, maintenance therapies. Children: > 80% complete remission and finish 2 3 years, over. Adults: 65- 85% complete remission, less than 40% survival (very poor prognosis for phil+) Myeloperoxidase, sudan black stain, combined esterase stain (granulocytes stain red, monocytes stain black) 75% achieve remission with induction therapy, less than 30% cured. Lack of antibodies (due to lack of functional b cells) Most cells end up in periphery usually not needed. Myeloid problem (that can lead to all or aml)! B symptoms+ fatigue, gout, splenomegaly, bone pain. Wbc elevated, platelets may or may not be elevated.
