HSS 4102 Lecture Notes - Lecture 2: Paracrine Signalling, Muscle Hypertrophy, Base Pair

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 4102
• Professor: Saulier & Phillips

Document Summary

Plasticity is part of normal development - dna is not the only determinant of phenotype: many examples where environment has a profound effect on a(cid:374) a(cid:374)i(cid:373)al"s phe(cid:374)ot(cid:455)pe i. e fish (cid:449)ho (cid:272)a(cid:374) (cid:272)ha(cid:374)ge ge(cid:374)der depe(cid:374)di(cid:374)g o(cid:374) (cid:374)ature"s (cid:374)eed. Morphs (ectomorphs): different phenotypes induced by the environments: genetically identical animals can have diff morphs aka mutants (if rare) or polymorphisms (if common, >5% of pop) Epigenetics: genetic mechs that create phenotypic variation w/o altering the base pair nucleotide sequence of the genes; varying the expression of genes. Agents of developmental plasticity: temperature-dependent phenotype temp diffs cause aa chains to fold differently and enzymes are turned off or on, enzymes activity as a function of temperature i. e tyrosinase is essential to produce melanin in. Siamese cats and himalayan rabbits: analogous conditions in humans in which only the hair at the extremities is pigmented g>a mutation, melanin protects us against uv light similar mechanisms in plants.