HSS 3305 Lecture 17: Lecture 17 – Diseases of the Endocrine System
1 Dec 2016
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Document Summary
Cells must be ready to respond to essential signals in their environment. Distant location in a multicellular organism endocrine signaling by hormones. Nearby cells paracrine stimulation by cytokines. Dependent on adjacent cells interacting contact-dependent. Endocrinologists are medical doctors who specialize in research and treatment disorders and diseases of the endocrine system. Group of specialized organs and body tissues that produce, store, and secrete chemical substances known as hormones. The major organs of the endocrine system. During pregnancy, the placenta also acts as an endocrine gland in addition to its other functions. Cross cell membrane to bind with receptors inside of the cell. Steroid-receptor complex acts as transcription factor to regulate gene expression. Examples: estrogens, progesterone, androgens (testosterone), glucocorticoids, mineralocorticoids. Circulating steroid hormones often bound to a carrier protein or binding globulin. Carrier proteins-glycoproteins produced in liver and other site specific locations. Estrogen, testosterone carried by sex hormone binding globulin (shbg) and small amount by serum albumin.
