HSS 2305 Lecture Notes - Lecture 20: Inositol Trisphosphate, Apoptosis, Lipid Bilayer

• School: University of Ottawa
• Department: Health Sciences
• Course: HSS 2305
• Professor: Shannon Bainbridge

Document Summary

Lecture 20 signal transduction, ip3, dag, and pkc. Review the function of g protein-coupled receptors. Review adenylyl cyclase camp second messenger signaling pathway. G protein couple receptors cgmp second messenger signaling camp mediated changes in gene transcription. Mechanisms through which cell membrane phospholipids can become second messengers. G protein couple receptors ip3 and dag second messenger signaling. Role of pkc and ca2+ signaling in human health and disease. 2 major routes of message transmission: generation of an intracellular second messenger via an effector enzyme. Second messengers activate/inactivate target proteins: recruit signaling proteins to their intracellular domains to initiate a protein activated cascade. Fraction of pka translocate to nucleus p-creb. Binds to cre response element (tgacgtca) Gat ( transducin") effector enzyme = cgmp phosphodiesterase (pde) Gat triggers activation of cgmp phosphodiesterase (effector/enzyme) Decrease in cytosolic cgmp closes cgmp-dependent na+ and ca2+ ion channels. Membrane hyperpolarization signal to visual center. Bradyopsia (slow vision) mutations in genes encoding rgs9.