BPS 2110 Lecture Notes - Lecture 18: Hmg-Coa Reductase, Cytochrome P450, Amoxapine
25 Nov 2016
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Bps 2110 lecture 18: during metabolism, a drug may be bio-transformed into a pharmacological form that is: active, inactive, or both, drugs undergo full, partial, or no biotransformation, most metabolic biotransformation take place in the liver. Most natural drug products will be transformed into an inactive metabolite: when the administered drug is pharmacologically inactive while its metabolite is. Active , the administered drug is referred to as a prodrug : the inactive metabolite is usually, more water soluble, more ionized, less capable to bind to blood proteins & tissues, less capable of penetrating cell membranes, less toxic. A drug that is administered with no therapeutic threat will have one once the drug is formed through metabolism. Four principal chemical reactions are involved in the metabolism of drugs: oxidation, reduction, hydrolysis, conjugation. Oxidation: generally catalysed by liver enzymes i. e. oxidases, example: Reduction: generally catalysed by liver & gut enzymes i. e. reductases, example:
