HLSC 3473U Lecture Notes - Lecture 7: Sarcopenia, Telomere, Homeostasis
Document Summary
Module 7 frailty as a complex chronic condition among older adults. Characteristics of a complex chronic condition: more than one chronic disease/condition, healthcare utilization, psychosocial, environmental, and lifestyle factors, multiple self-management requirements or social supports are required. A biologic condition of increased vulnerability to stressors that results from decreased physiological reserves and multi-system dysregulation, limited capacity to maintain homeostasis and to respond to internal and external stresses. Frailty can be summarized as an aggregate expression of risk resulting from age or disease associated decline. 3-7% of people over age 65 years are frail. 20-26% of people in their 80"s are frail. Increased risk of geriatric syndromes, dependency, disability, hospitalization, institutional placement, and mortality. Level 1 cellular changes oxidative damage, telomere shortening. Level 2 system dysregulation: hematocoagulatory dysfunction, endocrine dysfunction, metabolic dysfunction and inflammatory pathway dysregulation. Level 3 system impairment: musculoskeletal impairment: sarcopenia, function impairment, neurocognitive impairment: sensory loss and mood disturbances.
