HLSC 2110U Lecture Notes - Lecture 22: Pregnenolone, Circadian Rhythm, Tyrosine
11 Apr 2019
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Document Summary
Synthesized as prohormones and then clipped to mature form or embedded within a larger precursor. Synthesized in er packed in golgi secreted either by. Regulated secretion: cell stores hormones and then releases it in bursts. Constitutive secretion: cell does not store hormones and releases them when synthesized. First step and rate limiting step of synthesis is the conversion of cholesterol to pregnenolone. Synthesis of pregnenolone from cholesterol happens on the inner membrane of the mitochondria. From that point, synthesis goes back and forth from mitochondria to er. Bound in plasma with low affinity and non-specifically. Hypothalamus produces a range of hormones that act on the anterior (6) or posterior (2) pituitary to stimulate secretion of hormones. Produce pth interacts with vit d to stimulate release of calcium from bone and increase reuptake of calcium by kidney. Produces cholecalciferol which is a precursor of vit d.
