BIOL 2050U Lecture Notes - Wild Type, Cytokine, T-Cell Receptor
Document Summary
Both t and b cells are necessary for antibody response to antigen. T cells don"t secrete antibodies once activated; they just proliferate sole function of thymus is to make t cells. T cells recognize short linear aa stretches (approx. Det. only recognize proteins (no cho"s) antigens must be presented on apc (antigen presenting cell) Mhc restriction t cells only respond to host apc"s indicates there must be a genetic link link is the major histocompatability complex lots of polymorphism in the mhc between individuals. Mhc: (hla in humans) encodes cell surface proteins recognized by t cells. 3 classes of genes (i, ii, iii) class human. Class i expressed everywhere except rbc, neural tiss. Class ii b cells, macrophages, dendridic cells. **these genes are highly polymorphic** balanced polymorphism no wild-type exists. ***a t cell recognizes one of the several expressed mhc on an apc*** T cell antigen receptors receptors behave as a unit that simultaneously identifies ag and mhc.
