KIN429 Lecture Notes - Lecture 2: Osteoprotegerin, Sclerostin, Skeletor

• School: University of Waterloo
• Department: Kinesiology
• Course: KIN429
• Professor: Lora Giangregorio

Document Summary

Growth plate: if a column is too tall, the indian hedgehog won"t make it to the top of the column and the cells won"t make pthrp. Chondrocytes divide (proliferate) in a layer within the growth plate. As they secrete chondrocyte collagen, they get further embedded in the growth plate. Eventually they stop proliferating and then get bigger (hypertrophy: hypertrophic chondrocytes secrete hormones and proteins that control the growth. They make a factor called vegf that attracts the bone marrow. They also direct mineralization of the cartilage between the. Hypertrophied chondrocytes secrete indian hedgehog, which goes to the round chondrocytes. This causes secretion of pthrp (parathyroid hormone related protein) The growth plate is too short and the bone does not grow in length. In mice without pthrp, the condition can be reversed by adding the activating receptor for. He was 6"7 tall, but his bones were weak. Problems were cured with estrogen treatment fused the growth plates, and the bone became.