KIN429 Lecture Notes - Osteoid, Small Cell, Biomineralization

• School: University of Waterloo
• Department: Kinesiology
• Course: KIN429
• Professor: Lora Giangregorio

Document Summary

"cell suicide") apoptosis regulated by proteins from other cells. Others will remain on the surface of the new bone and differentiate into lining cells. The rest undergo apoptosis (cell suicide) and disintegrate. Local regulators cells: bone cells produce molecules that communicate with other, these molecules are called growth factors and cytokines, local regulators because they act on nearby cells, control cell division (proliferation), differentiation, and survival, growth factors. Bone morphogenetic proteins (bmps) bind to bmp receptors on mesenchymal stem cells causing the cells to produce cfba 1, which activates transcription. When cbfa 1 activates the genes, the cells differentiate into mature osteoblasts. Without cbfa 1, the cells would turn into fat cells. Insulin-like growth factors (igfs) are produced by osteoblastic cells in response to several bone active hormones, such as parathyroid hormone and estrogens, or bmps. Igfs accumulate in bone matrix and are released during the process of bone remodeling by osteoclasts.