KIN404 Lecture Notes - Lecture 4: Brown Adipose Tissue, Leptin Receptor, Leptin
29 Jan 2019
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Kin 404 section 1 regulation of energy intake lecture 4. Circulating hormones influencing energy homeostasis via the arcuate nucleus. The hypothalamus interprets and integrates a number of neural and humoral inputs to coordinate feeding and energy expenditure in response to conditions of altered energy balance. Long-term signals communicating information regarding the body"s energy stores, endocrine status and general health are predominantly humoral. Short-term signals, including gut hormones and neural signals from higher brain centres and the gut, regulate meal initiation and termination. Both short- and long-term signals can also affect energy expenditure via sympathetic nervous outflow to brown adipose tissue and by effecting the secretion of various pituitary hormones. The adipose tissue-derived hormone leptin the kingpin hormone in an endocrine. Leptin: a product of the ob gene discovered in 1994. Leptin receptor (lr): multiple isoforms; all products of a single gene (db, lepr) discovered in 1995: lrb is crucial for leptin action.
