KIN217 Lecture 16: lecture-16-part-2.PDF
29 Apr 2018
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Department
Course
Professor
Chap'ler 21 - ft+\ Acrd Degradation
frrt as E:el
rcI trrth g$<zn \rnKag€S /
g op.'
'htghty redr.ced,h,g\ etorage capacrty (no waLer)
'BUT m\rs+
I stored \n a
. rhrbugho.r y
-> sqbcutnnects (bclow {he skrn)
u+ vrscerul (around lhe rrrternol orgon)
A trtframusc\ltOr TAG
(,tSrrrg trri as Firef r
t-+ g s{nages +b r€.t€a€e enengy frorn adtpose *rssr.rq
i) Decln'caticxr o{ a'drpose tlq +o "teo.. f.a+*, oests d into *he b\ood frr *ranspc
rnrtochondrio. fo" o.lggtfo n
3) De<lrcctcr{-vcn oT the. to++y acrds +o .acet1r'c}A for, grocessrng b5 lhe
Acid\"
of\
low btood g\ucDSe crl (need acety\ rids
brecrEctc,.tfl or lpol {o'
act rvah€cl " 'rrvr 3Hzo
' Phcsghorylated 3 H+
It
C
L+ ongo.ntzes fa+ drog\e{ so -t AG <-rcress,bte-
L+ relases c^drpo6e frig\Icende \ipose_ (ATGL)
H retecses z.u FA _ MA6
'-)3""F4 6 g\yceror re,\eosed by rnu.ocrcg\g\yceror rrgas€,
i{es..115 oF Re\ea:e V
g\!c€{-o\
+
fot\ acids
i,rokein Kincrse ft
Op*l: on fer,\1pi64 FtS
r\Pas€ Uy yhosphryla€ion)
L-+aKtt' ' hve'r =+ DHAp4 Slycerol [ehude it -phosy]c,t€
Dente.r \y5t( or g\vC-orreogo.i-,esr Sq\\ce.o \
,t\osphate,
prlQ\Pnar <-
6fg'l rvci r:6 gg 116 t q
€<]rqs
Jrvc€ro\
$lcerot L- g\Yc€co\
3 -\'hosPnol€
NADF{
g\lcerol + |a*\ a4rd,
<in0e not ro\ubie rn
0qve&\ So\\r{ro,A
dihydrox r.1Oce+o^-g
phosphate -* b-gtyce(aldel-rg6n.a
3 -phosPhot(-
NQD +
,Slepl *"/\chivcr
'Fa*ty aqds <.ntef
H Constderab\ VS: pro+e.tn rne.dioled *ransport
. once h cell
- A"ul- Cof+ rs o.ctded +o fo*ty ocrds (Acyf ._CoA Sgr*hetos
. Trop f_"+\ ocid rn ce\l
r'\rrtcchcnclc rc"\ rn (lt'r\ x
Ocq\ C &vn\tin€ a\tor^re-r
to ?ctss +hfoqgn,
fn€mb \'; ng
\n cYfoP\asrvr-
e-xchcinqi€.
CATI
- Acg\ corni+lno
cFrf t\
-1{'19 rho'*rrY -/
'----.-
FA! FRbdz
dcq\ Cot ;5;- 1s61irSAz-enoq\ CoA
ri\ \ .'"\2
\':-, o htd(at\on f
L-3 -qclroxYaci
------.a \
@ )\ o",ao
+\f* - \
-- .,1/
\ C.o(
L\ o r]
(_s
t-> FsrrnS oCety\ CoA t a
+ (Horno\ogrrs +o ?hosgha€e b<zrng odded {c g\rrcos€-) {rap 3\..rCose
" 2 +eP r€qctron Lur{h CrCy\ croe.ng\ot€- ri,\Ferm(<\rc\k. {orrned *hen Cr,tt
. NoTE : ATP -r AM p
'+need to coun{ oS Z /+rP uri<=r\ (another ATp+AMp = zADp)
ATP AMP * PP;
\v
Fo\ ocrA + HS- CoA --\l-- Acq\ -CoF NO[E, trosyn\hef,c feo.t'{cr-.r &n
acg\ Cotr
Ccenzun^g sYA+he+ose
r) Fa\t! acrd + A--P acv\ ade''\y\ate +P
>tcp l"-''G.et +he [at\ [*cct Fc ]Y-a. frrc\t,-rx
'A+\ octdS for oxidotron n€€d to g<.t *o {h'e
H No Acal- coA transpor+er
' CoA exchonge {or carnr*ine
+ ca{o\yrd l"J camrtrne ac\\mnsterqse- \
- Trohsgor*ed tnfo
-'Irom\ucas€
'\n rnatr'rx, fal-ty ocid +GhsQerred bocr *o CoF
b ca.,.,f rn€, dcy\*ronsfemse if (Cnrf\
Sl-ep;3.Lt,S,6 '' bqictcre the Fc-.\*y Ac,dS'
" Known 4S [4 -ort,dcrtior\
'Fovr reoct\ons +hod ore rePec*€d
Llytdds u-3-hgdroxyaAl Lr'A
+ g*rtero+es 3.'- tretoacg\ co A f NftD H
u1 by u-3 hydroxyacyl ctehydrcg<ncsgG
6) Clecrvcg€ c+ {{ne 3-re*oacy\ coA
tcery/ Ag\ con + carnr{rn€
* bJ throlos( @
2 corbons shor+ec
