HLTH101 Lecture Notes - Lecture 14: Depressant, Stimulant, Leonardo Dicaprio

• School: University of Waterloo
• Department: Health Studies
• Course: HLTH101
• Professor: Diane Williams

Document Summary

Drug intake can produce profound immediate activity changes in many bran regions. Vta, sublenticular and extended amygdala cocaine-induced rush. Amygdala and nucleus accumbens influence both the rush and the craving for more drug, which becomes stronger as the euphoria wears off. Under normal circumstance, the amount of dopamine at a synapse is controlled in part by the reuptake of dopamine by the transmitting neuron. At synapse, there is area between neuron synaptic ending and dendrites on receiving (synaptic cleft), and that is where neurotransmitters are released. Dynorphine = a protein that quiets dopamine release so now you need more cocaine to get the same high (vta are releasing less dopamine now) 2 ways of adjusting concentration in neuro synapse: increasing concentration through presynaptic or taking up (re-uptake) of dopamine. Some are excitatory (glutamine and dopamine) increase response. Individual factors - body mass, general health, genetic factors, concurrent.