BIOL239 Lecture Notes - Lecture 5: Sister Chromatids, Synaptonemal Complex, Nuclear Membrane

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S-phase: dna is synthesized and chromosomes are duplicated to produce identical sister chromatids (bipartite chromosomes, sister chromatids remain joined at the centromere, metacentric chromosomes have x shape, acrocentric chromosomes have y shape. G2-phase: cell is synthesizing proteins necessary fro mitosis and impending. Prophase/prometaphase: chromosomes condense, 2 centrosomes (formed in s phase) migrate to each pole of the cell, nuclear membrane breaks down, microtubules invade the nuclear area, sister chromatids attach to microtubules at the kinetochore. Metaphase: chromosomes align on the metaphase plate, sister chromatids are facing opposite poles. Anaphase: sister chromatics separate at centromere, separated sister chromatids move to opposite poles, disjunction = separation. Telophase: final duplication of the nucleus, nuclear membrane reforms and spindle fibers disappear, chromosomes uncoil and become a tangle of chromatin, cytoplasm divides. Cytokinesis: cytoplasm divides and the parents cell is split into two identical daughter cells with identical genetic information.

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