BIOL130 Lecture Notes - Lecture 5: Sigma Factor, Negative Number, Phosphodiester Bond
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17 Dec 2016
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Synthesize new rna molecule based upon complimentary based pairing based on one of the two strands. The strand that will actually define the sequence of new rna molecule made, is defined as the template strand. Remember, when making a nucleic acid, always synthesizing or adding new nucleosides triphosphates on the 3" hydroxyl group, so it is made from the 5" to the 3" end. In order to align the new rna to the dna, we have to do this in an antiparallel fashion. So we are reading the template strand in the 3" to 5" direction in order to make an anti-parallel rna molecule in a 5" to 3" direction. Incoming nucleosides will be in their triphosphate form and the way we synthesize the correct nucleoside triphosphates is by having complimentary base pairing of we how we position them. We need an enzyme to catalyze the phosphodiester bond. Enzyme that is actually mediating the whole rna process is rna polymerase.
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