BIOL130 Lecture Notes - Lecture 40: Active Transport, Apoptosis, Tethering

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Anaerobic eukaryotic cell engulfed the prokaryotic aerobic cell. This turned into the mitochondria, turned eukaryotes in aerobes. Precursors of eukaryotes believed to have no endomembrane system: plasma membrane carried out all membrane-related functions. Endomembrane system evolved as invagination of plasma membrane. Protein sorting = the transfer of proteins into the compartments they are needed in. Synthesis of all proteins starts in cytosol on free ribosomes. A stretch of amino acids that directs proteins to organelles: present for nucleus, mitochondria, chloroplast, peroxisomes, and er, removed after sorting. Very high traffic through pores, even though they are selective. Proteins imported must have a nuclear localization sequence. Synthesis of protein in cytosol by free ribosomes. The nuclear import receptor guides the protein with the signal to the nucleus: needs this signal for the nuclear receptor to recognize it. After it is in the nucleus the import receptor is recycled. Nuclear pore complex gateway to the nucleus.

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