BIOL130 Lecture Notes - Lecture 12: Mitosis, Plectin, Conformational Change

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Cytoskeleton: system of protein filaments in the cytoplasm of a eukaryotic cell that gives the cell shape and the capacity for directed movement. Its most abundant components are actin filaments, microtubules, and intermediate filaments: highly dynamic structure that is continuously reorganized as a cell changes shape, divides, and responds to its environments. Intermediate filaments: fibrous protein filament (about 10 nm in diameter) that forms rope-like networks in animal cells. Often used as a structural element that resists tension applied to the cell from outside: enable cells to withstand the mechanical stress that occurs when cells are stretched, smooth muscle cells is where they were first discovered. Intermediate filaments are the toughest and durable filaments. When cells are treated with concentrated salt solutions and non-ionic detergents, the intermediate filaments survive while ,most of the other filaments get destroyed. The mesh of intermediate filaments, the nuclear lamina, underlines and strengthens the nuclear envelope in all eukaryotic cells.

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