PHPY 304 Lecture Notes - Lecture 7: Bradycardia, Urinary Retention, Atenolol

• School: U of S
• Department: Physiology and Pharmacology
• Course: PHPY 304
• Professor: Desai Kash

Document Summary

Regional ischemia coronary artery disease / angina: knowledge objectives. Ischemia: not having enough blood through coronary arteries due to narrowing. Occurs with activity or stress: treatment: m. nitroglycerin, isosorbide for prophylaxis (nitrate), diltiazem (benzothiazepine), verapamil (phenylalkylamine), 1-blockers (metoprolol, atenolol, variant/vasospastic: angina at rest that occurs in cycles, treatment: m. nitroglycerin, isosorbide for prophylaxis (nitrate), diltiazem (benzothiazepine), verapamil (phenylalkylamine), Ways to treat: reduce oxygen demand and decrease work load on heart, cardiac contractility; heart rate & venous return, m: nitrates, blockers, ca2+ channel blockers. Increase oxygen supply to heart by promoting vasodilation: vasodilation, m: nitrates, ca2+ channel blockers. Drugs to consider & drug groups used: nitrates, nitroglycerin, isosorbide dinitrate, 1-adrenergic blockers, metoprolol, atenolol, calcium channel blockers (ccbs, diltiazem, verapamil, amlodipine, nifedipine. Nitrates: acute angina: potent vasodilator, mechanism: myocardial wall tension & o2 demand rapid action due to, venodilation. Venous return to heart: preload, work load on heart.