PATH 205.3 Lecture Notes - Lecture 22: Osteogenesis Imperfecta, Achondroplasia, Rheumatoid Arthritis
Document Summary
Osteosarcoma: define osteoarthritis, explain the pathogenesis of degenerative joint disease and describe its pathology, define rheumatoid arthritis and explain its pathogenesis and pathology. What is the pathologic basis of heberden"s nodes? . Epiphysis = the end part of long bones: covered by a cartilage cap, which forms a joint with another long bone, epiphyseal growth plate = endochondral ossification occurs here; it lays down cartilage that will become bone. Metaphysis = the narrow portion of long bone b/w the epiphysis and diaphysis; where blood supply to the bone enters. Diaphysis = the shaft or central part of the long bone: the main component of the bone that gives it length and strength, have bony spicules and bone marrow. Components of bone: cells, osteoblasts lay down osteoid, pth, vit c, vit d, osteocytes pth, vit d, Calcitonin: matrix, collagen, glycoproteins, mineral calcium hydroxyapatite, are mature osteoblasts, non-mineralized matrix may be called, osteoclasts pth, vit d,
