PATH 205.3 Lecture Notes - Lecture 10: Cancer, Intraepithelial Neoplasia, Bone Marrow Suppression
Document Summary
# of cells in cell cycle (stain for ki-67) *tumors more than 2mm will need blood supply. It wills secrete substances that will create new blood vessels (neoangiogenesis). Clinical significance of this is that one can cut the blood supply to the tumor to kill it: side effects of chemotherapy, hair loss, diarrhea, bone marrow suppression: infections, hemorrhage. Carcinoma-in-situ: local invasion = benign tumors remain localized while malignant tumors invade adjacent tissues. Stromal reaction: fibrosis (when extensive called desmoplasia) makes it gritty to cut. Exophytic = grow outward beyond epithelial surface. Endophytic (ulcers) = grow inward into tissues. Diffuse thickening: hemorrhage (red, necrosis (yellow, desmoplasia (whitish and hard) It"s an attempt to lay down fibrous tissue. Mobile = not fixed to surrounding tissue. Irregular (looks like a cauliflower: metastasis = unequivocal evidence of malignancy. Successful transplantation of a malignant tumor to a new site.
