PATH 205.3 Lecture Notes - Lecture 7: Coronary Artery Disease, Aortic Aneurysm, Heart Failure
Document Summary
Learning outcomes: explain the pathogenesis of atherosclerosis. *pulmonary artery is the only artery that carries deoxygenated blood. *pulmonary vein is the only vein that carries oxygenated blood. Heart statistics: 72 beats per min, 103,680 per day, 728,252 per wk, 3,155,760 per month, 37,869,120 per year, 2,900,000,000 per, 7,568 litres/day, 53,162 l/wk, 230,370 l/mo, 2764445 l/yr, 211,700,000 l/lifetime, 1,331,552 barrels/ lifetime lifetime. Cardiovascular disease kills more people than any other disease. Atherosclerosis causes 80% of all cardiac disease. The most important disease of the cardiovascular system. Atherosclerosis = a chronic inflammatory, proliferative disease of the arteries fueled by risk factors that induce endothelial injury. The hallmark of atherosclerosis is endothelial injury (hallmark = major contributor of the disease) Tissue becomes necrotic smooth muscles will try to push the plaque into the lumen the diameter of the lumen will decrease tissue will become ischemic. Lethal ischemia, if left untreated, can lead to irreversible cell necrosis or myocardial infarction.
