BMSC 200 Lecture Notes - Lecture 10: Amide, Protein Structure, Hydrogen Bond

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Important point: the nature of the peptide bond is conserved regardless of whatever two amino acids you"re linking together. Within each peptide bond, it has the ability to donate and accept a hydrogen bond. Protein folding general: its going to be the. !1 side chains in the core and the hydrophilic side chains on the outside-that was going to be the main driving force of it. There"s a tendency for things to move towards the lowest energy state. If we reduce the number of conformations possible and move towards the native structure, theres going to be less and less options available so it decreases the entropy (disorder). Ex) if you went from having 100 conformations down to 50, theres less disorder associated with those 50, and they are going to be of lower energy than the original 100 because they"re going into a lower energy state.

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