BIOL 120 Lecture Notes - Lecture 5: Fluid Mosaic Model, Lipid Bilayer, Red Blood Cell

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Researchers later developed a tem technique called freeze fracture which allowed them to look at the membrane in great detail: cells frozen in liquid nitrogen ( 196 celsius) then cracked with a knife blade, cells split along weakest point which h is often between the layers of membranes, researchers could see dark spots in the membranes and realized they were proteins in the lipid matrix, can get idea of how big proteins and protein complexes are by using this technique. Fluidity keeps membranes intact and functioning, allows cells to change shape: imagine the amoeba with a solid membrane (not possible), transport vesicles couldn"t form without a flexible membrane system, altered by lipid type, length, and other components (cholesterol, longer lipids give nonpolar tails more interactions and will make the membrane more viscous, more double bonds in the fatty acids will introduce less order (kinks in fatty acids) and make the membrane more fluid.

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