MBIO 2020 Lecture Notes - Lecture 7: Intein, Protein Splicing, Protein Folding

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blushseal731

25 Nov 2017

School

University of Manitoba

Department

Microbiology

Course

MBIO 2020

Professor

Anne

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Document Summary

Termination of translation: release factors (rf-1, rf-2, rf-3) recognize a nonsense codon on mrna in a site, rfs bind to the stop codon, peptidyl trasnferase adds water instead of an amino acid to the growing polypeptide. Hydrolyzes the peptide form the last trna: may require 1 more gtp, polypeptide is released form trna in p site. Alanine is aged to the polypeptide: 2. Translation continues through mrna portion: ~10 amino acids are added finishes with a stop codon, 3. Sequence of amino acids added is specific: 4. Signals a protease to degrade the defective protein. Removal of formyl group form fmet: 2. Removal of fmet: removal of a few amino acids from n terminus, 4. Addition of carbohydrate to make glycoprotein: glycosylation, not common in bacteria (at least not in e. coli, 5. Addition of lipid to make a lipoprotein: 6. Association with other polypeptides to make an oligomeric protein.

Related Questions

1. _________________________ is the name of the process that produces proteins using RNA molecules.

a.Transcription

b Translation

c. Replication

d. Mutagenesis

2. The peptide bonding site on the ribosome:

a. A site

b. P site

c. E site

d. D site

3. The name given to the bond formed between two amino acids.

a. Hydrogen bond

b. Double bond

c. Peptide bond

d. Negative bond

4. __________________________ is the movement of the mRNA molecule on the ribosome to open up the A-site for the new incoming amino acid.

a. Transformation

b. Mutation

c. Translocation

d. Initiation

5. What does the term semi-conservative mean.

a. Replication of RNA is semi-conservative, each new strand consists of one old strand of RNA and one new strand of RNA.

b. Replication of DNA is semi-conservative, each new strand consists of one old strand of DNA and one new strand of DNA.

c. Replication of DNA is semi-conservative, each new strand consists of new strands of nucleotides.

d. Transcription of RNA is semi conservative.

6. This molecule functions during protein synthesis to recognize the codon and bring the proper amino acid back to the ribosome for translation.

a. mRNA

b. tRNA

c. rRNA

d. DNA polymerase

7. What is meant by the base-pairing rule.

a. Bases on a single strand of DNA are always found as pairs

b. Adenine always base pairs with guanine; cytosine with thymine

c. Adenine always base pairs with thymine; cytosine with guanine

d. Bases on a single strand of RNA are found in pair.

8. In this step of protein synthesis, amino acids are added to a growing polypeptide chain.

a. Initiation.

b. Elongation.

c. Termination.

d. Transpiration.

9. Three complementary bases found in a mRNA are called ____________________.

a. Anti-codon.

b. Triplet.

c. Doublet.

d. Codons.

10. Which statement best describes the job or function of the messenger RNA.

a. Carries the map of the gene sequence in the form of codons to the cytoplasm

for translation of the protein.

b. It transfers amino acids to the ribosome for protein synthesis.

c. It forms the ribosomes.

d. It helps replicate DNA.

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MBIO 2020 Lecture Notes - Lecture 7: Intein, Protein Splicing, Protein Folding

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