BIOL 2500 Lecture Notes - Lecture 18: Quantitative Trait Locus, Phenotypic Trait, Ronald Fisher
20 Mar 2017
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Multiple gene hypothesis: this hypothesis attempts to explain complex phenotypic trait variation in a population by assuming a polygenic model (interaction of many genes) In this model, alleles of each gene obey the principles of segregation and independent assortment, and have an additive effect in the production of phenotypic variation: the foundation of quantitative genetics. Individuals being studied should be a random sample with respect to the trait being studied. It interprets how much variation exists within the sample: write formula. Standard deviation (s) the deviation from the mean: s = square root of s^2. Interactive variance (vi) - epistatic interactions between alleles of genes contributing to a quantitative trait. Four attributes of heritability are central to its meaning. Identical or monozygotic (mz) twins are produced via a single fertilization followed by a splitting event: 100% of the alleles are shared, vp=ve.
