BIOL 2420 Lecture 16: Lecture 16

• School: University of Manitoba
• Department: Biological Sciences
• Course: BIOL 2420
• Professor: W.G.Anderson

Document Summary

Metabolic reactions are highly sensitivity to [h+], and this ecf ph is tightly regulated. Ecf ph regulated by excreting h+ in the urine and by reabsorbing" hco3- form the. Ii) ph > 7. 45 - alkalosis (more rare than acidosis) Ecf ph regulated by secreting less h+ into the ltrate and excreting excess hco3- in the urine. Disturbances to acid-base balance may be respiratory or metabolic in origin. Buffering systems involved in regulating extracellular uid ph: bicarbonate/carbonic acid, proteins - more relevant in the icf, hemoglobin - buffer against changes in carbonic acid, phosphate buffering system. Changes in pco2, brought about by hypo- or hyperventilation, cause the ph to shift. Increasing the concentration of one substance involved in a reversible reaction drives that reaction towards the opposite side. If the underlying cause of the ph disturbance is of respiratory origin, compensation can only be achieved via the kidneys. Ph disturbances arising from acids and bases of non co2 - origin.