BIOL 2410 Lecture Notes - Lecture 6: Resting Potential, Electrochemical Gradient, Nernst Equation

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Outline: membrane potential and resting membrane potential, equilibrium potentials. Nernst equation: how resting membrane potential is established, movement of ions causes changes in membrane potential. Ions are charged - either + or - The body is electrically neutral - for every cation there is an anion. Cells maintain gradients by ions by means of primary active transport: requires energy to separate charge. Conservation of charge - net charge is always 0. Opposite charges are attracted to each other. Charges move through conductors, and are separated by insulators: conductors - water - its everywhere. K+ is major cation, phosphate is major anion within cells. Na is major cation, cl is major anion outside the cell. Ions are not distributed evenly between ecf and icf. Inside has net negative charge, outside has net positive charge - electrical disequilibrium. Electrochemical gradient - combination of an electrical gradient and chemical gradient. Ions subjected to an electrochemical gradient will move.

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