TOX 4000 Lecture Notes - Lecture 2: Xenobiotic, Sarin, Circulatory System

• School: University of Guelph
• Department: Toxicology
• Course: TOX 4000
• Professor: Craig Bailey

Document Summary

Lecture 5: toxicodynamics/mechanisms of toxicity sept. 19. Interpret descriptive toxicity studies: estimate probability that a xenobiotic is toxic, develop plan to mitigate xenobiotic toxicity, rational design of new pharmaceuticals, industrial chemicals and pesticides. Step 1: delivery (actual interaction between toxicant and target molecule is most important: absorption: Transfer of a chemical from the site of exposure to the systemic circulation. Lipid solubility most important factor affecting absorption (lipid soluble absorbed more readily) Rate of absorption depends on many factors: presystemic elimination. During transfer from site of exposure to systemic circulation, toxicants may be eliminated. Can contribute to injury of lungs, liver, and digestive mucosa because these processes promote their delivery to these sites: distribution of toxicant either to or away from its target, reabsorption vs. excretion, toxication vs. detoxification. Step 3: cellular dysfunction: the role of the target molecule determines the effect.