PSYC 2410 Lecture Notes - Lecture 6: Standardized Test, In Situ Hybridization, Plethysmograph
31 May 2018
School
Department
Course
Professor
RESEARCH METHODS OF BIOPSYCHOLOGY
▪ Methods of studying nervous system
o Visualizing the living brain
▪ X ray
• Contrast
o How
▪ Radio opaque material injected
▪ Absorb x rays more
o What
▪ Structure
• Computerized tomography
o How
▪ Rotating x ray gun and detector
o What
▪ Structure
• 3d
• not high resolution
▪ Radioactivity
• Position emission tomography
o How
▪ 2 deoxyglucose injected
▪ then taken up by active cells
o what
▪ activity
• estimate
▪ Magnetic field
• Magnetic resonance imaging
o How
▪ Radio frequency waves in magnetic field stimulate
hydrogen atoms to emit waves
▪ Those waves are then measured
o What
▪ Structure
• 3d
• high spatial resolution
• functional magnetic resonance imaging
o how
▪ measures increase in oxygen flow to all active brain
areas
o what
▪ BOLD signal
• Structural and functional
find more resources at oneclass.com
find more resources at oneclass.com
• Spatial resolution better
• Real time
• diffusion tensor imaging
o how
▪ diffusion of water molecules along tracts
o what
▪ axonal tract imaging
• interconnectivity
▪ Transcranial stimulation
• Magnetic
o How
▪ Use magnetic field to create temporary lesion
• Direct current
o How
▪ Temporarily stimulate area of cortex
o Recording human psychophysical activity
▪ CNS
• Brain activity
o Scalp electroencephalography
▪ How
• Scalp electrodes
▪ What
• EEG signal
o Sum total of electrical events in
brain
o Consciousness
▪ Alert (Low amplitude, fast
EEG)
▪ Relaxed (High amplitude,
slow EEG)
o Magnetoencephalography
▪ PNS
• SNS activity
o Muscle tension
▪ Measured by electromyogram
o Eye movement
▪ Measured by electrooculogram
• ANS activity
o Skin conductance
▪ Electric charge on skin do to functioning of sweat
glands
• Level
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
Intracellular unit recording: microelectrode inside neuron, extracellular unit recording, microelectrode near neuron, multiple unit recording, large electrode for many nearby neurons. Implant electrode: pharmacological research methods, routes of drug transmission, peripheral, feeding, put in food or drink of subject. Injected into the peritoneal cavity of the abdomen. Immunocytochemistry: how, animal creates and binds antibodies to antigen label antibody with dye inject antigen. In situ hybridization: genetic engineering, gene, knockout, create organisms lacking a specific gene, replacement, replace one gene with another, protein, green fluorescent, how, expose to blue light. Insert gfp into target cells: brainbow, how, each neuron is labelled with a different colour, behavioural research methods of biopsychology, neuropsychological testing, modern approach, single test, standardized test battery, customized test battery, common test battery. Intelligence: wechsler adult intelligence scale, 11 subtests, verbal scale, performance scale, memory. Involves: unconditional stimulus, unconditional response, conditional stimulus, conditional response, operant.
