PATH 3610 Lecture Notes - Lecture 10: Vasoconstriction, Effusion, Lymph Node

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vice

Document Summary

Response to injury: permanent cells (cannot be replaced, stable cells, labile cells (stem cells) Healing: regenerating the cells that have been lost/injured. Regeneration: to regenerate you need stem cells, organs cannot regenerate, tissues can regenerate, cells (except permanent) can regenerate, neurons of the brain, skeletal cells, cardiac myocyte are permanent, cannot regenerate. Cell cycle regulation: epidermal growth factor (urine or saliva helping to heal wounds, mostly in animals than humans, transforming growth factor. Insulin like growth factor: fibroblast growth factor, vascular endothelial growth factor. What regulates a cell cycle: hormones (stimulates at distance, growth factors (stimulate or inhibit growth, cytokines, embryonic stem cells (can regrow neurons, heart cells etc. , however if stimulated they can create cancerous cells, adult stem cells. Cell death: macroscopic/gross processes (visible to eye, histological processes (study of tissues at microscopic level, molecular pathways and subroutines. Macroscopic appearance: coagulative cell death- dry gangrene (localized death, caseous dead tissue is dry and crumbly (looks like cheese)