PATH 3610 Lecture Notes - Lecture 1: Resting Potential, Myelin, Axon Hillock

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Process starts with physiological research at cell/molec levels. If drug effective at low conc in vitro then chance of working in vivo and not be toxic tested in rats or mice 90% of drugs tested in experimental animals are too toxic for further development. Phase 1 clinical trials drug tested on healthy human volunteers to text toxicity how metabolized, how removed from blod by liver and kidney, how effectively administered, etc. Phase 2 clinical trials drug tested on target human pop. Phase 4 clinical trials tests other uses of drug. Less the 10% make it through to become approved and marketed. Regulatory mechanisms share a function: maintain constancy of the internal environment = homeostasis maintained by negative feedback loops. 384-322 b. c aristotle speculated on function of human body. 304-250 b. c erasistratus first to study physiology as attempted to apply physical laws to understand human function. 130-210 a. d galen wrote on subject and considered supreme authority until renaissance.