PATH 3610 Lecture Notes - Lecture 1: Fibrinoid Necrosis, Mitochondrial Permeability Transition Pore, Coagulative Necrosis

• School: University of Guelph
• Department: Pathology
• Course: PATH 3610
• Professor: Andrew Vince

Document Summary

Overview of cell injury and cell death. Chapter 1 notes: cell injury: results when cells are stressed so severely that they are no longer able to adapt or when cells are exposed to damaging agents or suffer from abnormalities (ex: in. Dna or proteins): reversible cell injury: in early stages of injury the functional and morphological changes are reversible if the damaging stimulus is removed. There may be significant structural and functional abnormalities. The injury usually has not progressed to severe membrane damage and nuclear dissolution: cell death: with continuing damage, the injury becomes irreversible, at which time the cell cannot recover and it dies. 2 types of cell death: necrosis, apoptosis. Both types of cell death differ in their mechanisms, morphology, and roles in disease and physiology. Necrosis: when damage to membranes is severe, enzymes leak out of lysosomes, enter the cytoplasm, and digest the cell.