NUTR 4090 Lecture Notes - Lecture 17: Therapeutic Index, Cyp3A4, Active Metabolite
17 Apr 2018
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Uncontrolled growth of abnormal cells: caused by genetic mutations (oncogenes and tumor suppressor genes, tumor suppressor genes are unable to tell cell to die. If you have mutation in oncogene there is constant signal telling cell to proliferate. Tumor = formed by abnormal cells: benign abnormal growth, pre-malignant, malignant cell can detach and migrate slide 6. 40% increase in next 20 years, life expectancy is going up. Baby boomers are getting older which will affect many. Initiation irreversible dna mutations: promotion propagate and accumulate mutations, progression tumor formation. As they grow larger, they draw blood supply and can detach. Common myeloid progenitor incapable to function what they are supposed to perform. Massive accumulation of these immature cells results in death. Well conserved by species genetically passed on by evolution. Kids died faster than (cid:449)hen they (cid:449)eren"t gi(cid:448)en folic acid. All from understanding how nutraceuticals should not be used. Block folic acid and get no cell growth.
