NUTR 3360 Lecture Notes - Lecture 21: Blood Sugar, Leptin, White Bread
2 Nov 2016
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Document Summary
Tg accumulation in the liver due to a imbalance between tg uptake into the liver and breakdown/removal: diet, de novo lipogenesis, adipose tissue. Liver injury that occurs with nafld resembles that which occurs from alcoholic liver disease. Nafld is associated with obesity, insulin resistance, and dyslipidemia. Liver function blood test biomarker of liver inflammation/injury: aspartate (ast) or alanine (alt) aminotransferase, alkaline phosphatase (alp, increased alt (alanine aminotransferase) is associated with higher. Bmi, waist to hip ratio, and circulating insulin, tg and leptin. The role of diet in nafld the food"s effect on blood glucose level. Compared mice fed with high vs. low gi diet. High gi diet increased % body fat, decreased insulin sensitivity, and increased blood and liver tg. Anaerobic exercise vs. calorie restricted diet + exercise. Improvements in steatohepatitis is correlated with improvements in bmi, waist circumference, blood alt levels, and homa-ir score.
